Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 19(1): 158-62, 2009 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19019676
ABSTRACT
Aryl aminopyrazole amides capped with N-alkylbenzamides 13-16 are selective glucocorticoid receptor agonists. 2,6-Disubstituted benzamides have prednisolone-like potency or better in vitro. Good oral exposure was demonstrated in the rat, with compounds with lower lipophilicity, for example N-hydroxyethyl benzamides (e.g., 16e).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Benzamidas
/
Receptores de Glucocorticoides
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2009
Tipo de documento:
Article