Experience of maintenance infliximab therapy for refractory ulcerative colitis from six centres in England.
Aliment Pharmacol Ther
; 29(3): 308-14, 2009 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-19035973
ABSTRACT
BACKGROUND:
Infliximab is used for treatment of Crohn's disease and, following the Active Ulcerative Colitis Trials (ACT) 1 and 2, it has been used as rescue and maintenance therapy in moderate and severe ulcerative colitis (UC).AIM:
To report on English experience with maintenance infliximab in terms of response and colectomy rates and side-effect profile in UC.METHODS:
A retrospective audit conducted by using a web-based questionnaire filled in by 12 gastroenterologists from six English centres.RESULTS:
Of the 38 patients receiving induction with infliximab, 28 (73.6%) maintained an ongoing response (8-weekly infusions 5 mg/kg) for a mean duration of 16.8 months (range 4-59), with 21 (55.3%) being in remission. Three of 38 patients (7.9%) who also responded had a secondary loss of response after an average of 10 months (range 8-13); seven of 38 patients (18.4%) showed no response. The colectomy rate was seven of 38 (18.4%, five non-responders and two with secondary loss of response). Adverse effects occurred in five patients (13.2%). Two discontinued infliximab (alopecia, invasive breast cancer). The three less-severe adverse effects were acute and delayed-type hypersensitivity reactions and one persistent otitis media.CONCLUSION:
Our experience suggests acceptable response rates, colectomy rates and side-effect profile of maintenance therapy with infliximab in moderate and severe UC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Padrões de Prática Médica
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Fármacos Gastrointestinais
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Colite Ulcerativa
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Colectomia
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Anticorpos Monoclonais
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Aliment Pharmacol Ther
Ano de publicação:
2009
Tipo de documento:
Article