Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone.
Epilepsy Res
; 83(2-3): 261-4, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19059761
ABSTRACT
SUMMARY:
The present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block G(s) opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression of tolerance were inhibited by ultra-low doses of naltrexone, suggesting the possible involvement of G(s)-coupled opioid receptors in the development of tolerance to the anticonvulsant effect of morphine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Analgésicos Opioides
/
Morfina
/
Anticonvulsivantes
/
Naltrexona
/
Antagonistas de Entorpecentes
Limite:
Animals
Idioma:
En
Revista:
Epilepsy Res
Ano de publicação:
2009
Tipo de documento:
Article