A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
Nat Genet
; 41(1): 89-94, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19060909
ABSTRACT
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
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Jejum
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Receptores de Melatonina
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Receptor MT2 de Melatonina
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Diabetes Mellitus Tipo 2
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Adolescent
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Adult
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Child
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Humans
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Middle aged
Idioma:
En
Revista:
Nat Genet
Ano de publicação:
2009
Tipo de documento:
Article