Enhancement of cell-mediated cytotoxicity by Clostridium difficile toxin A: an in vitro study.
Toxicon
; 29(4-5): 417-28, 1991.
Article
em En
| MEDLINE
| ID: mdl-1907410
ABSTRACT
Cells from the immune system exhibiting cytotoxic activity are able to kill tumor or infected cells in a major histocompatibility complex-restricted (cytotoxic lymphocytes) or non-restricted (natural killer cells) manner. In order to exert such a cytotoxicity they have to bind the target cell and release cytotoxic factors able to induce target cell death. Treatment of human peripheral blood mononuclear cells with toxin A from Clostridium difficile induced an enhancement of the cytotoxic efficiency of these effector cells. Morphological analysis of effector/target cell pairs seems to suggest that this could be related to an increased ability of cytotoxic effectors to establish close and intertwined contacts with target cells. These contacts involve adhesion molecules and lead to the formation of a "closed chamber" which probably improves the efficacy of lytic factors and results in an increased cytotoxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
/
Clostridioides difficile
/
Citotoxicidade Imunológica
/
Enterotoxinas
Limite:
Humans
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1991
Tipo de documento:
Article