Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors.
Bioorg Med Chem
; 17(2): 621-4, 2009 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-19091578
ABSTRACT
Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Piridazinas
/
Rhinovirus
/
Proteínas do Capsídeo
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2009
Tipo de documento:
Article