Inner border--a specific and significant colposcopic sign for moderate or severe dysplasia (cervical intraepithelial neoplasia 2 or 3).
J Low Genit Tract Dis
; 13(1): 1-4, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19098598
ABSTRACT
OBJECTIVE:
Investigation of the correlation between the colposcopic sign inner border and cervical intraepithelial neoplasia (CIN) 2 or 3 and its association with specific human papillomavirus (HPV) types and the age of the patient. STUDYDESIGN:
Colpophotographs or cervicograms were taken from 947 women referred due to an abnormal cervical finding. Occurrence of the colposcopic sign inner border was evaluated retrospectively by 2 independent colposcopists. Histologic evaluation was based on punch or cone biopsies. Human papillomavirus testing was done using Hybrid Capture I or a polymerase chain reaction-based HPV test.RESULTS:
The prevalence of the colposcopic phenomenon inner border in women with an atypical transformation zone was 7.6% (53/695). In 70% of women with inner border, CIN 2 or 3 was confirmed histologically. The sensitivity of the colposcopic sign inner border for detection of CIN 2 or 3 was 20%, and the specificity was 97%. In patients with inner border, the odds ratio for CIN 2 or 3 was 7.7 (95% CI=4.2-14.3). There was no significant association between inner border and any high-risk HPV type. Cervical intraepithelial neoplasia 2 or 3 associated with inner border was significantly more frequent in patients younger than 35 years.CONCLUSION:
Inner border is a rare colposcopic phenomenon but highly specific for CIN 2 or 3 in young women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Displasia do Colo do Útero
/
Neoplasias do Colo do Útero
/
Colposcopia
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Infecções por Papillomavirus
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Low Genit Tract Dis
Ano de publicação:
2009
Tipo de documento:
Article