Enantioselective sequential conjugate addition-allylation reactions: a concise total synthesis of (+)-podophyllotoxin.
Org Lett
; 11(3): 597-600, 2009 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-19105659
ABSTRACT
A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Podofilotoxina
/
Produtos Biológicos
/
Cinamatos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2009
Tipo de documento:
Article