Cystic disease of the liver following prenatal and perinatal exposure to aflatoxin B1 in rats.
J Gastroenterol Hepatol
; 6(4): 359-62, 1991.
Article
em En
| MEDLINE
| ID: mdl-1912444
ABSTRACT
Experiments were designed to elucidate the differences, if any, in the liver histology induced by aflatoxin B in newborn and adult animals. The transfer of toxic metabolites from pregnant rats to their litters was confirmed by thin layer chromatography of liver homogenates in the latter. Extensive cystic lesions of the biliary and hepatic type developed only in young animals. Multifocal hepatic necrosis, bile ductular proliferation, areas of altered hepatocytes, neoplastic nodules and hepatocellular carcinoma constituted the total spectrum in both adult and newborn animals. Increased susceptibility to the toxins early in life appears to be responsible for this intriguing phenomenon. These aspects may have a bearing on the genesis of childhood liver disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Aflatoxina B1
/
Cistos
/
Doença Hepática Induzida por Substâncias e Drogas
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Gastroenterol Hepatol
Ano de publicação:
1991
Tipo de documento:
Article