Alzheimer abnormalities of the amygdala with Klüver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease.
Arch Neurol
; 66(1): 125-9, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19139311
ABSTRACT
BACKGROUND:
Neurofibrillary tangles and beta-amyloid plaques have been observed in the amygdala in Alzheimer disease. A disproportionate abundance of this abnormality in the amygdala may cause behavioral symptoms similar to Klüver-Bucy syndrome.OBJECTIVES:
To describe an atypical behavioral presentation of Alzheimer disease and to review the literature on the subject.DESIGN:
Case study.SETTING:
Outpatient specialty clinic. PATIENT A 70-year-old man with progressive behavioral symptoms of hyperorality, hypersexuality, hypermetamorphosis, visual agnosia, hyperphagia, and apathy who died at age 77 of asphyxiation on a foreign object. MAIN OUTCOMEMEASURES:
Clinical symptomatology, brain imaging, and neuropathology.RESULTS:
The pathologic diagnosis was Alzheimer disease with abundant tangles and plaques in the lateral amygdala.CONCLUSIONS:
This case represents a variant of Alzheimer disease with prominent amygdala abnormalities and a Klüver-Bucy phenotype that was misdiagnosed as frontotemporal dementia. Clinical and imaging findings that may aid in accurate diagnosis are reviewed.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Kluver-Bucy
/
Doença de Alzheimer
/
Tonsila do Cerebelo
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Arch Neurol
Ano de publicação:
2009
Tipo de documento:
Article