Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population.
Mol Hum Reprod
; 15(2): 121-30, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19141488
ABSTRACT
Pregnancy and parturition involve a complex and poorly understood molecular and biological interplay between mother and fetus. Inflammatory cytokines have been reported to be associated with fetal growth and parturition. The aim of this study was to examine whether common proinflammatory cytokine polymorphisms are associated with preterm birth (PTB), low birthweight or intrauterine growth restriction in a Japanese population. We assessed a consecutive series of 414 women who had singleton deliveries in Sapporo, Japan between 2001 and 2005. Genotyping of IL1A -889C/T, +4845G/T (A114S), IL1B -511C/T, -31C/T, IL2 -384T/G and IL6 -634C/G polymorphisms was determined by an allelic discrimination assay. The risk of PTB significantly increased in women carrying the IL1A -889T allele (CC genotype [reference]; CT genotype, odds ratios (OR) 2.5; 95% confidence intervals (95% CI) 1.4-4.8; CT+TT genotypes [dominant genotype model], OR 2.5, 95% CI 1.3-4.6). Similarly, the risk of PTB significantly increased in women carrying the IL1A +4845T allele (GG genotype [reference]; GT genotype, OR 2.4, 95% CI 1.3-4.4; GT+TT genotypes [dominant genotype model], OR 2.3, 95% CI 1.2-4.2). The frequency of the IL1A TT haplotype in mothers with PTB was significantly higher than in mothers who had a term birth (P < 0.001), whereas the frequency of the IL1A CG haplotype in mothers who had a PTB was significantly lower (P < 0.001). Our findings suggest that the polymorphisms and haplotypes in the IL1A gene are associated with PTB in Japanese women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Recém-Nascido de Baixo Peso
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Citocinas
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Povo Asiático
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Nascimento Prematuro
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Mol Hum Reprod
Ano de publicação:
2009
Tipo de documento:
Article