Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract.
J Ethnopharmacol
; 122(2): 379-83, 2009 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-19162158
ABSTRACT
AIM OF STUDY Bidens pilosa has traditionally been used as an anti-diabetic phytomedicine. However, its alleged benefits and mechanism remain elusive. This study aimed to evaluate the effect and action of Bidens pilosa water extract on type 2 diabetes. MATERIALS AND METHODS:
A daily dose of Bidens pilosa water extract or glimepiride, a positive control, was given orally to C57BL/KsJ-db/db mice once or for 28 days. Levels of blood glucose, serum insulin, and glycosylated hemoglobulin A1C, glucose tolerance, and islet structure were used to evaluate its anti-diabetic effects in db/db mice. Rat pancreatic islets and streptozocin-treated mice were tested for insulin-releasing mechanism of Bidens pilosa water extract.RESULTS:
A daily dose of Bidens pilosa water extract given once or for 28 days significantly decreased blood glucose levels and increased serum insulin levels in db/db mice. Besides, 28-day treatment with Bidens pilosa water extract significantly improved glucose tolerance, decreased HbA1C levels and protected islet structure in db/db mice. Mechanism study showed that Bidens pilosa water extract stimulated insulin secretion via pancreatic islets.CONCLUSIONS:
Our results suggest that Bidens pilosa water extract ameliorates type 2 diabetes in db/db mice via regulation of insulin secretion and islet protection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
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Bidens
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Diabetes Mellitus Experimental
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Hipoglicemiantes
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Insulina
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Fitoterapia
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2009
Tipo de documento:
Article