[Rhodiola sachalinensis suppresses T241 fibrosarcoma tumor cells proliferation in vitro and growth in vivo].

OBJECTIVE: To study the anticancer activity of Rhodiola sachalinensis in vitro and in vivo experiments. METHODS: The effect of Rhodiola sachalinensis extracts at various concentrations on T241 fibrosarcoma cells proliferation and cytotoxic potential were measured. We divided T241 fibrosarcoma-bearing C57Bl6/J mice into two groups, the tumor inhibition rate were observed. RESULTS: Rhodiola sachalinensis extracts inhibited T241 tumor cells growth in a dose-dependent manner. The concentrations of Rhodiola sachalinensis extracts from 50 microg/ml to 250 microg/ml did not reduced the survival rate of T241 tumor cells. The daily administration of Rhodiola sachalinensis resulted in a significant suppression of the growth of primary tumors, compared to control group, tumor inhibition rate in Rhodiola sachalinensis group reached 70.9%. CONCLUSION: Rhodiola sachalinensis can inhibit T241 tumor cells growth and does not cause a direct cytotoxicity against tumor cells in vitro and in vivo.