[Fine mapping of a pure paroxysmal kinesigenic dyskinesia family].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 26(1): 1-5, 2009 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-19199241
OBJECTIVE: To fine map the gene responsible for pure paroxysmal kinesigenic dyskinesia in a Chinese family. METHODS: Six additional markers flanking the tightly linked markers were chosen in the candidate region resulting from a whole genome-wide scanning and tested by parameter and nonparameter analysis using Linkage and Genehunter softwares to fine map the candidate region. RESULTS: Evidence for linkage of the pure paroxysmal kinesigenic dyskinesia to chromosome 3 was further confirmed. A maximum two-lod score of 2.82 at theta=0 was obtained with D3S3669. Critical recombinants place the PKD gene between D3S1314 and D3S1265. CONCLUSION: A new locus of pure paroxysmal kinesigenic dyskinesia (PKD) is localized within a 10.2 cM interval on 3q28-29, between markers D3S1314 and D3S1265.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linhagem
/
Coreia
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Mapeamento Cromossômico
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Ano de publicação:
2009
Tipo de documento:
Article