Antiphosphatidylserine-prothrombin complex antibodies in 3 patients with Behçet disease involving superficial vein thrombophlebitis.
Arch Dermatol
; 145(2): 171-5, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19221262
ABSTRACT
BACKGROUND:
Superficial vein thrombophlebitis is the common vascular symptom in Behçet disease and is characterized as erythema nodosum-like eruptions. Some studies have reported the presence of antiphospholipid antibodies (Abs) in patients with Behçet disease. OBSERVATIONS We measured lupus anticoagulant, anticardiolipin, anti-beta(2)-glycoprotein I, and antiphosphatidylserine-prothrombin complex antibody (Ab) levels in 3 patients with Behçet disease involving superficial vein thrombophlebitis. High levels of IgM antiphosphatidylserine-prothrombin complex Abs were found (mean [SD], 50.3 [43.1] U/mL; normal, <10 U/mL). One of the patients with Behçet disease was positive for both IgM and IgG antiphosphatidylserine-prothrombin complex Abs, and 2 were positive for lupus anticoagulant. Two patients were also positive for IgM anticardiolipin Abs, but the titers were low. In contrast, none of the patients with Behçet disease was positive for IgG anticardiolipin Abs or IgG or IgM anti-beta(2)-glycoprotein I Abs.CONCLUSIONS:
A high titer of IgM antiphosphatidylserine-prothrombin complex Abs was found in our patients with Behçet disease involving superficial vein thrombophlebitis. We speculate that there is a relationship between the antiphospholipid Abs, especially IgM antiphosphatidylserine-prothrombin complex Abs, and superficial vein thrombophlebitis complications in Behçet disease. This study suggests that elevated serum antiphosphatidylserine-prothrombin complex Ab levels might play some role in the development of the vascular manifestations in Behçet disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilserinas
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Tromboflebite
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Protrombina
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Síndrome de Behçet
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Anticorpos Antifosfolipídeos
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Tela Subcutânea
Tipo de estudo:
Etiology_studies
Limite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Arch Dermatol
Ano de publicação:
2009
Tipo de documento:
Article