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Antiphosphatidylserine-prothrombin complex antibodies in 3 patients with Behçet disease involving superficial vein thrombophlebitis.
Kawakami, Tamihiro; Yamazaki, Masahide; Mizoguchi, Masako; Soma, Yoshinao.
Afiliação
  • Kawakami T; Department of Dermatology, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan. tami@marianna-u.ac.jp
Arch Dermatol ; 145(2): 171-5, 2009 Feb.
Article em En | MEDLINE | ID: mdl-19221262
ABSTRACT

BACKGROUND:

Superficial vein thrombophlebitis is the common vascular symptom in Behçet disease and is characterized as erythema nodosum-like eruptions. Some studies have reported the presence of antiphospholipid antibodies (Abs) in patients with Behçet disease. OBSERVATIONS We measured lupus anticoagulant, anticardiolipin, anti-beta(2)-glycoprotein I, and antiphosphatidylserine-prothrombin complex antibody (Ab) levels in 3 patients with Behçet disease involving superficial vein thrombophlebitis. High levels of IgM antiphosphatidylserine-prothrombin complex Abs were found (mean [SD], 50.3 [43.1] U/mL; normal, <10 U/mL). One of the patients with Behçet disease was positive for both IgM and IgG antiphosphatidylserine-prothrombin complex Abs, and 2 were positive for lupus anticoagulant. Two patients were also positive for IgM anticardiolipin Abs, but the titers were low. In contrast, none of the patients with Behçet disease was positive for IgG anticardiolipin Abs or IgG or IgM anti-beta(2)-glycoprotein I Abs.

CONCLUSIONS:

A high titer of IgM antiphosphatidylserine-prothrombin complex Abs was found in our patients with Behçet disease involving superficial vein thrombophlebitis. We speculate that there is a relationship between the antiphospholipid Abs, especially IgM antiphosphatidylserine-prothrombin complex Abs, and superficial vein thrombophlebitis complications in Behçet disease. This study suggests that elevated serum antiphosphatidylserine-prothrombin complex Ab levels might play some role in the development of the vascular manifestations in Behçet disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Tromboflebite / Protrombina / Síndrome de Behçet / Anticorpos Antifosfolipídeos / Tela Subcutânea Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Dermatol Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Tromboflebite / Protrombina / Síndrome de Behçet / Anticorpos Antifosfolipídeos / Tela Subcutânea Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Dermatol Ano de publicação: 2009 Tipo de documento: Article