Mechanism of action of clinically approved adjuvants.
Curr Opin Immunol
; 21(1): 23-9, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19246182
ABSTRACT
Aluminum-containing adjuvants continue to be the most widely used adjuvants for human use. In the last year a major breakthrough has been the realization that alum adjuvant triggers an ancient pathway of innate recognition of crystals in monocytes and triggers them to become immunogenic dendritic cells, nature's adjuvant. This recognition can occur directly, via the triggering of the NALP3 inflammasome by alum crystals, or indirectly through release of the endogenous danger signal uric acid. It is also clear now that adjuvants trigger the stromal cells at the site of injection, leading to the necessary chemokines that attract the innate immune cells to the site of injection. How exactly these pathways interact remains to be determined.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Adjuvantes Imunológicos
/
Citocinas
/
Células Th2
/
Compostos de Alúmen
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Ano de publicação:
2009
Tipo de documento:
Article