Differential calcium signalling in neuronal-glial networks.
Front Biosci (Landmark Ed)
; 14(6): 2004-16, 2009 01 01.
Article
em En
| MEDLINE
| ID: mdl-19273181
ABSTRACT
Calcium ions are the probably the most ancient, the most universal and omnipresent intracellular signalling molecules, which are involved in regulation of a host of cellular functional reactions. In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuroglia
/
Sinalização do Cálcio
/
Neurônios
Limite:
Humans
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Ano de publicação:
2009
Tipo de documento:
Article