In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.
Antimicrob Agents Chemother
; 53(5): 2136-8, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19289531
ABSTRACT
In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pythium
/
Azóis
/
Equinocandinas
/
Antifúngicos
/
Naftalenos
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2009
Tipo de documento:
Article