Paraoxonasel phenotype distribution in Thais.
J Med Assoc Thai
; 92(3): 405-12, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19301736
ABSTRACT
OBJECTIVE:
To determine the PON1 activity and phenotype distribution in a Thai population. STUDYDESIGN:
Prospective Descriptive study. MATERIAL ANDMETHOD:
Between October 2001 and April 2002, 160 healthy Thai individuals aged 20-74 years were assessed for PON1 activity and the phenotype distribution by using dual substrate method.RESULTS:
The means +/- SD of basal, salt-stimulated paraoxonase and arylesterase activities were 239.7 +/- 83.9 nmol/min/mL 555.2 +/- 222.2 nmol/min/mL and 147.6 +/- 33.8 micromol/min/mL respectively. The authors observed a wide interindividual variability up to 6.9-fold for paraoxonase activity and 4.6-fold for arylesterase activity. The authors found a range of ssPON/ARE ratio from 1.04 to 7.05 and three distinctive phenotype modals of AA (1.04-2.25), AB (2.44-4.29), and BB (4.53-7.05) with frequencies of 14.4% (AA), 51.9% (AB), and 33.7% (BB). The authors also observed the association of sex with lipid parameters and PON1 activity.CONCLUSION:
The distribution of PON1 phenotype in Thais is clearly trimodal with high frequency in BB phenotype.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arildialquilfosfatase
/
Povo Asiático
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Genética Populacional
Tipo de estudo:
Diagnostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Med Assoc Thai
Ano de publicação:
2009
Tipo de documento:
Article