Inhibition of microtubule assembly is a possible mechanism of action of mitoxantrone.
Biochem Biophys Res Commun
; 180(1): 118-23, 1991 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-1930209
ABSTRACT
We have found that mitoxantrone can inhibit the polymerization of brain tubulin in a dose dependent manner. MXT had relatively high affinity for tubulin but had no appreciable effect on tubulin associated guanosine-triphosphatase (GTPase) activity nor could it compete with vinblastine (VB) and colchicine (Col) for tubulin binding sites. Furthermore, MXT (0.1-10 microM) is antiproliferative to cold-treated (0 degree C) epithelial cells after only brief exposure (30 min). These results indicated that MXT is a microtubule inhibitory agent and can exert its anticellular effect through modulation of microtubule assembly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mitoxantrona
/
Microtúbulos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1991
Tipo de documento:
Article