Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett
; 19(8): 2354-9, 2009 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-19303288
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureia
/
Epóxido Hidrolases
/
Descoberta de Drogas
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2009
Tipo de documento:
Article