Studies on 8-methoxypsoralen tolbutamide interactions in vitro and in vivo.
Farmaco
; 46(4): 579-92, 1991 Apr.
Article
em En
| MEDLINE
| ID: mdl-1930554
ABSTRACT
The present study aimed at characterizing the influence of tolbutamide on the distribution of 8-methoxypsoralen (8-MOP) in mouse serum and organs. Experiments performed in vitro clearly showed that tolbutamide causes competitive displacement of 8-MOP from its binding sites on human serum albumin. Similarly, the amount of labelled compound(s) bound in serum after oral administration of 3H-8-MOP to mice was significantly reduced when tolbutamide was given by the same route. The quantitative distribution of radioactivity from 3H-8-MOP in mouse tissues varied according to organ (liver, intestine, skin, etc.,), and was maximum in the organs of elimination. In all the organs studied, the administration of tolbutamide 2 hours after that of 3H-8-MOP caused a dose-dependent reduction of the radioactive compound(s) present in tissues, suggesting that tolbutamide may accelerate the excretion of 8-MOP and/or its metabolites from the body.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolbutamida
/
Metoxaleno
Limite:
Animals
Idioma:
En
Revista:
Farmaco
Ano de publicação:
1991
Tipo de documento:
Article