Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines.
Org Lett
; 11(7): 1575-8, 2009 Apr 02.
Article
em En
| MEDLINE
| ID: mdl-19320504
ABSTRACT
By employing an intramolecular Pd(0)-mediated ring opening of an acylnitroso-derived cycloadduct, new hydroxamic acid containing benzodiazepines have been synthesized and have demonstrated biological activity in MCF-7 and PC-3 tumor cell lines. Subsequent N-O bond reduction of the hydroxamate has provided access to amide analogues for SAR studies. During the course of our syntheses, an intermediate oxazoline N-oxide was isolated and gave insight into the mechanism of the key Pd(0)-mediated reaction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzodiazepinas
/
Ácidos Hidroxâmicos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2009
Tipo de documento:
Article