Polyethylene glycol interferon alpha-2b-induced immune-mediated polyradiculoneuropathy.
Intern Med
; 48(7): 569-72, 2009.
Article
em En
| MEDLINE
| ID: mdl-19336961
ABSTRACT
Polyethylene glycol-interferon alpha (PEG-IFNalpha) has been used as the standard treatment for hepatitis C virus (HCV) infection. There have been no previous reports of polyradiculoneuropathy with anti-ganglioside antibodies induced by PEG-IFNalpha-2b. We report a 59-year-old man who developed polyradiculoneuropathy during treatment with PEG-IFN alpha-2b for chronic HCV infection. Serum levels of anti-asialo-GM1 (GA1) and anti-GM1 antibodies were elevated. Cessation of therapy with double filtration plasmapheresis resulted in marked improvement in his symptoms accompanied by a reduction in the antibody level. PEG-IFN alpha-2b may induce peripheral neuropathy mediated by anti-GA1 and anti-GM1 antibodies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Polietilenoglicóis
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Polirradiculoneuropatia
/
Interferon-alfa
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Doenças Autoimunes do Sistema Nervoso
/
Transtornos Neurológicos da Marcha
Limite:
Humans
/
Male
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Middle aged
Idioma:
En
Revista:
Intern Med
Ano de publicação:
2009
Tipo de documento:
Article