HIV type 1 group M subtype G in Cameroon: five genome sequences.
AIDS Res Hum Retroviruses
; 25(4): 469-73, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19361281
ABSTRACT
Near full-length viral genome sequences were obtained for five putative subtype G candidates identified in HIV-infected Cameroonian blood donors, based on partial genome sequences for the gag, pol, and env regions. Phylogenetic analysis of the genome sequences shows that all five strains are pure subtype G with no indication of intersubtype recombination. The Cameroon subtype G sequences did not form a geographically based subcluster and were intermixed within the subtype G branch with isolates from several different countries. HIV-1 group M subtype G accounts for only 4.5% of HIV infections in Cameroon. However, genome segments of subtype G are present in 67% of all infections and 80% of infections due to intersubtype recombinant strains in Cameroon. The addition of five subtype G genome sequences to the HIV database may contribute to a better understanding of the origins and classification of HIV-1 subtypes and CRFs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
HIV-1
/
Genoma Viral
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Ano de publicação:
2009
Tipo de documento:
Article