Anti-coxsackie virus B3 norsesquiterpenoids from the roots of Phyllanthus emblica.
J Nat Prod
; 72(5): 969-72, 2009 May 22.
Article
em En
| MEDLINE
| ID: mdl-19374435
ABSTRACT
Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Sesquiterpenos
/
Medicamentos de Ervas Chinesas
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Enterovirus Humano B
/
Phyllanthus emblica
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Glicosídeos
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2009
Tipo de documento:
Article