[Myofibrillar protein tropomyosin and allergic cross-reactivity].

ABSTRACT

Myofibrillar protein tropomyosin (TM) is a normal physiological protein participating in regulation of muscular contraction. It is widely prevalent among living organisms. This explains cross-reactivity of allergic patients to home dust, sea fish, cockroaches, etc. The presence of similar IgE-binding epitopes in TM of different origin is a key factor in development of cross-reactivity (CR). CR to TM is a general biological phenomenon. We consider modified TM as a basic component in design of allergovaccines of a new generation.