Food reduces isoniazid bioavailability in normal volunteers.
J Assoc Physicians India
; 39(6): 470-1, 1991 Jun.
Article
em En
| MEDLINE
| ID: mdl-1938852
ABSTRACT
Food and drug interaction is a major variable in bioavailability of drugs. Isoniazid is the most common antitubercular drug used in India. We studied the effect of standard Indian breakfast and lunch on the bioavailability of isoniazid in a single dose crossover study in normal male volunteers. The standard breakfast and lunch significantly reduced plasma AUC, Cmax and Kabs values of isoniazid. Isoniazid, thus, should not be administered with food.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Alimentos
/
Isoniazida
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Assoc Physicians India
Ano de publicação:
1991
Tipo de documento:
Article