Chloro-oxime derivatives as novel small molecule chaperone amplifiers.
Bioorg Med Chem Lett
; 19(11): 3128-35, 2009 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-19398333
ABSTRACT
Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC(50)<10 microM).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Chaperonas Moleculares
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2009
Tipo de documento:
Article