Stereocontrolled synthesis of highly functionalized quaternary carbon centers: a route to alpha-substituted serines.
Angew Chem Int Ed Engl
; 48(23): 4202-5, 2009.
Article
em En
| MEDLINE
| ID: mdl-19415711
ABSTRACT
Three in a row! Highly functionalized quaternary amino polyols with three consecutive asymmetric carbon centers have been prepared through tandem hydroboration of allene 1 and addition to an aldehyde (see scheme; Cy = cyclohexyl, TBDPS = tert-butyldiphenylsilyl, Ts = 4-toluenesulfonyl). This one-pot process provides access to advanced intermediates for the enantioselective synthesis of alpha-substituted serines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serina
/
Carbono
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2009
Tipo de documento:
Article