[Angiogenesis in laryngeal squamous carcinoma and its prognostic significance].

ABSTRACT

Prognosis for laryngeal squamous carcinoma patients depends on numerous factors, and tumor-related angiogenesis is one of them. Our study was concerned with prognostic significance of intra-tumor vascular bed in such patients. Bioptic material was sampled from 61 patients, aged 34-77, after combined treatment at the Center's Clinic. Microvascular density, overall perimeter of vascular wall and overall vascular area were compared with such clinical characteristics as T stage, tumor cell differentiation and presence of regional metastases using t-test (Student) and contingency tables (2x2) (chi2, Fisher's accuracy criterion). The Caplan-Meyer method was used to evaluate survival and Cox F-test--to assess survival curve difference significance (p < or = 0.05). The angiogenesis pattern proved a significant prognosticator for relapse, relapse-free and specific survival.