GnRH analogue remarkably down-regulates inflammatory proteins in peritoneal fluid proteome of women with endometriosis.
J Reprod Med
; 54(4): 223-31, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19438164
ABSTRACT
OBJECTIVE:
To determine the changes in the peritoneal fluid proteome of women with endometriosis determined by the administration of gonadotropin-releasing hormone analogues (GnRH-a). STUDYDESIGN:
Peritoneal fluid samples were collected during laparoscopy from patients under GnRH-a and from women who did not receive any type of hormonal treatment in the 6 months before surgery. Samples were subjected to 2-D gel electrophoresis and compared by computerized analysis. Protein spots differentially expressed between the study groups were identified by liquid chromatography tandem mass spectrometry.RESULTS:
More than 470 protein spots were analyzed. Several proteins with significant alterations were found. The down-regulated molecules were isoforms of alpha 2-HS glycoprotein, alpha 1-antitrypsin, S100-A8, haptoglobin alpha chain and vitamin D-binding protein. No protein spot had significantly higher expression in peritoneal fluid of women under GnRH-a than in untreated patients.CONCLUSION:
Several inflammatory molecules present in peritoneal fluid are down-regulated during treatment with GnRH-a; administration of this drug reduces the inflammation in the peritoneal cavity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Líquido Ascítico
/
Proteínas
/
Hormônio Liberador de Gonadotropina
/
Endometriose
/
Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Reprod Med
Ano de publicação:
2009
Tipo de documento:
Article