The composition of untranslated regions in Trypanosoma cruzi genes.
Parasitol Int
; 58(3): 215-9, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19505588
ABSTRACT
We collected the UTRs from Trypanosomacruzi genes that have been experimentally mapped and are publicly available, and made a comprehensive analysis of their composition features including sequence length, G+C content and relationship to ORF, composition of the most frequent words, and distribution of Simple Sequence Repeats (SSR). T. cruzi UTRs exhibit range length of 10-400bp for 5' UTR and 17-2800 for 3' UTR. Both UTRs display mean G+C content of 40%. Ratios between the UTR and protein coding segments show that the 5' UTR is limited to a maximum of 20% of the total length in the final transcript. The 5' UTR most frequent words in the range 4-12 bases are almost exact complement to the 3' UTR respective words. SSR in 3' UTR are longer than in 5' UTR and are mostly derived from TA/AT, TG/GT, and TTA/ATT. SSR accounts up to 20% of the nucleotide composition in 5' UTR and up to 90% in the 3' UTR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma cruzi
/
Regiões 5' não Traduzidas
Limite:
Animals
Idioma:
En
Revista:
Parasitol Int
Ano de publicação:
2009
Tipo de documento:
Article