Association of serum uric acid levels with emotional and affective temperaments.

BACKGROUND: Temperament relates to emotions and the prevailing mood or affective temperament. Uric acid (UA) is the end-product of purine metabolism and has been associated with psychological features such as high energy/drive, positive affect, achievement, good performance, higher social status and leadership. METHODS: 129 subjects (44 males, 85 females) completed with the Combined Emotional and Affective Temperaments Scale, serum UA levels and a general health questionnaire. RESULTS: In the whole sample, serum UA levels were significantly correlated with disinhibition (r=0.36, p<0.001) and drive (r=0.25, p<0.01), but not with control, anger or any of the affective temperament scores. Among males, we found correlations at trend level (p>0.05 and <0.07) for control (r=0.27), irritable (r=0.29) and hyperthymic (r=0.27) affective temperaments. Among females, a significant correlation was found only with disinhibition (r=0.34, p=0.001). The top tertile of males (serum UA>6.0 mg/ml, n=16) had significantly higher drive (29.9+/-5.9x26.0+/-3.6, p=0.01) and higher control at trend level (21.2+/-3.1x19.3+/-2.9, p=0.054) than other males. Among women, the top tertile (serum UA>4.0 mg/ml, n=29) showed higher disinhibition scores (20.7+/-4.9x17.9+/-3.6, p<0.01) and more frequent choices of hyperthymic (8/26x6/59, p=0.023) and irritable temperaments (7/26x5/59, p=0.031) than the rest of the sample. Controlling for daily intake of meat and grains, which could lead to higher UA levels, did not change these results. LIMITATIONS: Small sample size for males. CONCLUSIONS: Externalized traits of temperament are associated with higher serum UA levels both in men and women.