Adult fulminant subacute sclerosing panencephalitis: pathological and molecular studies--a case report.
Clin Neuropathol
; 28(3): 213-8, 2009.
Article
em En
| MEDLINE
| ID: mdl-19537141
ABSTRACT
Subacute sclerosing panencephalitis is an uncommon progressive neurological disorder caused by a persistent defective measles virus, typically affecting children. We describe a case of fulminant subacute sclerosing panencephalitis in a 25-year-old male. Brain tissue biopsy showed histologic evidence of encephalitis with eosinophilic intranuclear inclusion bodies (Cowdry Type A and B), intracytoplasmic inclusion bodies, perivascular lymphoplasmacytic infiltration and gliosis. Immunohistochemical studies were positive using an anti-measles antibody. Reverse transcriptase-PCR detected measles virus RNA and phylogenetic analysis indicated a C2 genotype. The rare adult-onset form is often atypical and difficult to diagnose and should be included in the differential diagnosis of subacute "unexplained" neurological diseases and uncommon infectious disorders.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Panencefalite Esclerosante Subaguda
/
Encéfalo
/
Vírus SSPE
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Neuropathol
Ano de publicação:
2009
Tipo de documento:
Article