Polymorphisms in the Renin-Angiotensin system and outcome of very-low-birthweight infants.
Neonatology
; 97(1): 10-4, 2010.
Article
em En
| MEDLINE
| ID: mdl-19571582
ABSTRACT
BACKGROUND:
The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity.OBJECTIVE:
To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants.METHOD:
Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively.RESULTS:
There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus.CONCLUSION:
Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Base de dados:
MEDLINE
Assunto principal:
Sistema Renina-Angiotensina
/
Recém-Nascido de muito Baixo Peso
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Doenças do Prematuro
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Neonatology
Ano de publicação:
2010
Tipo de documento:
Article