Antiviral efficacy against hepatitis B virus replication of oleuropein isolated from Jasminum officinale L. var. grandiflorum.
J Ethnopharmacol
; 125(2): 265-8, 2009 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-19580857
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Jasminum officinale L. var. grandiflorum (JOG) is a folk medicine used for the treatment of hepatitis in south of China. Phytochemical studies showed that secoiridoid glycosides are the typical constituents of this plant. AIM OF THE STUDY The present study was undertaken to evaluate the effect of oleuropein (Ole) derived from the flowers of JOG on hepatitis B virus (HBV) replication in HepG2 2.2.15 cell line in vitro and duck hepatitis B virus (DHBV) replication in ducklings in vivo. MATERIAL AND METHODS:
The extracellular hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) concentrations in cell culture medium were determined by ELISA. DHBV in duck serum was analyzed by dot blot.RESULTS:
Ole blocks effectively HBsAg secretion in HepG2 2.2.15 cells in a dose-dependent manner (IC(50)=23.2 microg/ml). Ole (80 mg/kg, intraperitoneally, twice daily) also reduced viremia in DHBV-infected ducks.CONCLUSION:
Ole therefore warrants further investigation as a potential therapeutic agent for HBV infection.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Piranos
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Extratos Vegetais
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Vírus da Hepatite B
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Jasminum
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Antígenos de Superfície da Hepatite B
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Hepatite Viral Animal
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2009
Tipo de documento:
Article