Complementary chemoenzymatic routes to both enantiomers of febrifugine.

Wijdeven, Marloes A; van den Berg, Rutger J F; Wijtmans, Roel; Botman, Peter N M; Blaauw, Richard H; Schoemaker, Hans E; van Delft, Floris L; Rutjes, Floris P J T

Wijdeven, Marloes A; van den Berg, Rutger J F; Wijtmans, Roel; Botman, Peter N M; Blaauw, Richard H; Schoemaker, Hans E; van Delft, Floris L; Rutjes, Floris P J T.

Afiliação

Wijdeven MA; Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, NL-6525 AJ Nijmegen, The Netherlands.

Org Biomol Chem ; 7(14): 2976-80, 2009 Jul 21.

Article em En | MEDLINE | ID: mdl-19582308

ABSTRACT

ABSTRACT

Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the 3-hydroxypiperidine skeleton. The introduction of the quinazolone-containing side chain in both strategies was based on an N-acyliminium ion-mediated coupling reaction.

Assuntos

Piperidinas/síntese química; Quinazolinas/síntese química; Catálise; Piperidinas/química; Quinazolinas/química; Estereoisomerismo; Especificidade por Substrato

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Quinazolinas Idioma: En Revista: Org Biomol Chem Ano de publicação: 2009 Tipo de documento: Article

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