Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject.
Eur J Clin Nutr
; 63(9): 1123-9, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19584895
ABSTRACT
BACKGROUND:
Dietary flaxseed may have beneficial cardiovascular effects. An aged population has a higher incidence of cardiovascular disease, but they may react differently to flaxseed in the diet.OBJECTIVE:
To investigate the response, over a period of 4 weeks, of subjects aged 18-29 or 45-69 years to a diet containing the same amount of alpha-linolenic acid (ALA) (6 g) introduced in the form of ground flaxseed (30 g) or flaxseed oil.RESULTS:
All subjects who received flaxseed oil showed a significant increase in plasma ALA and eicosapentaenoic acid (EPA) concentrations over the course of this study. Subjects who received ground flaxseed in the 18-29-year-old group showed a statistically significant increase in their plasma ALA levels, and although there was a trend in the same direction for the 45-69-year-old subjects, this did not achieve statistical significance. The diets induced no major changes in platelet aggregation, plasma total cholesterol, low-density lipoprotein or high-density lipoprotein cholesterol levels in any of the groups. Younger subjects showed a decrease in triglyceride (TG) values compared with older subjects. There were no significant side effects that caused compliancy issues.CONCLUSION:
Subject age does not seem to be a major determining factor in influencing ALA absorption from a flaxseed-supplemented diet nor in the metabolism of ALA to EPA in the groups fed flaxseed oil. Concerns about side effects in older subjects administered a higher fiber load in a flaxseed-supplemented diet are not justified. However, younger but not older subjects showed a beneficial decrease in circulating TGs due to flaxseed supplementation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Gorduras na Dieta
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Ácido Eicosapentaenoico
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Ácido alfa-Linolênico
/
Linho
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Preparações de Plantas
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Absorção Intestinal
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Aged
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Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Nutr
Ano de publicação:
2009
Tipo de documento:
Article