Synthesis and structure-activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents.
Bioorg Med Chem Lett
; 19(16): 4626-9, 2009 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-19589676
ABSTRACT
A series of dicationic diaryl ethers have been synthesized and evaluated for in vitro antibacterial activities, including drug resistant bacterial strains. Most of these compounds have shown potent antibacterial activities. Several compounds, such as piperidinyl and thiomorpholinyl compounds 9e and 9l, improved the antimicrobial selectivity and kept potent anti-MRSA and anti-VRE activity. The most potent bis-indole diphenyl ether 19 exhibited anti-MRSA MIC value of 0.06 microg/mL and enhanced antimicrobial selectivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentamidina
/
Éteres Fenílicos
/
Benzimidazóis
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Enterococcus
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Resistência a Vancomicina
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Éteres
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Staphylococcus aureus Resistente à Meticilina
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Indóis
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Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2009
Tipo de documento:
Article