[Aspects of mammalian aging from alphaklotho study].
Nihon Rinsho
; 67(7): 1283-8, 2009 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-19591273
ABSTRACT
Since the discovery of alphaklotho-mutant mice, it has been questioned whether the responsible gene, alphaklotho, makes any effect on 'intrinsic aging' process. So far we found that alphaKlotho regulates transcellular calcium transport by mediating Na,K-ATPase activity and dominates mineral-regulating hormones such as PTH, vitamin D and FGF23. A new concept is now emerged that alphaklotho integrates mineral homeostasis. Findings of human cases with mineral disorders revealed impairment of alphaklotho expression as a pathological cause. Mineral metabolic system contributes to health and thus its disruption should result in acceleration of aging and disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glucuronidase
Limite:
Animals
Idioma:
Ja
Revista:
Nihon Rinsho
Ano de publicação:
2009
Tipo de documento:
Article