Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies.
Genome Biol
; 10(7): R77, 2009.
Article
em En
| MEDLINE
| ID: mdl-19607685
ABSTRACT
The recent advent of exon microarrays has made it possible to reveal differences in alternative splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage of the probe-level information on Affymetrix exon arrays when detecting differential splicing between sample groups. In comparison to existing ranking methods, the procedure shows superior reproducibility and accuracy in distinguishing true biological findings from background noise in high agreement with experimental validations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Splicing de RNA
/
Éxons
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Perfilação da Expressão Gênica
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Genome Biol
Ano de publicação:
2009
Tipo de documento:
Article