Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.
J Med Chem
; 52(16): 5241-52, 2009 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-19630384
ABSTRACT
Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure-activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very potent M(3) mAChR antagonist. The compound was functionally active and displayed greater than 24 h duration of action in a mouse model of bronchoconstriction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tropanos
/
Compostos de Bifenilo
/
Antagonistas Muscarínicos
/
Compostos Bicíclicos Heterocíclicos com Pontes
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2009
Tipo de documento:
Article