Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis.
J Child Neurol
; 24(10): 1268-72, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19687389
ABSTRACT
A pilot prospective follow-up study of the role of the branched chain amino acids as additional therapy to the ketogenic diet was carried out in 17 children, aged between 2 and 7 years, with refractory epilepsy. All of these patients were on the ketogenic diet; none of them was seizure free, while only 13 had more or less benefited from the diet. The addition of branched chain amino acids induced a 100% seizure reduction in 3 patients, while a 50% to 90% reduction was noticed in 5. Moreover, in all of the patients, no reduction in ketosis was recorded despite the change in the fat-to-protein ratio from 41 to 2.51. Although our data are preliminary, we suggest that branched chain amino acids may increase the effectiveness of the ketogenic diet and the diet could be more easily tolerated by the patients because of the change in the ratio of fat to protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epilepsia
/
Dieta Cetogênica
/
Aminoácidos de Cadeia Ramificada
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
J Child Neurol
Ano de publicação:
2009
Tipo de documento:
Article