Enhancement of guided-wave two-photon-excited luminescence response with a photonic-crystal fiber.
Appl Opt
; 48(28): 5274-9, 2009 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-19798365
ABSTRACT
Photonic-crystal fiber (PCF) is shown to substantially increase the guided-wave luminescent response from molecules excited through two-photon absorption (TPA) by femtosecond near-infrared laser pulses. With only a few nanoliters of TPA-excited molecules filling airholes in a specifically designed PCF, the guided-wave two-photon-excited luminescence (TPL) signal is enhanced by more than 2 orders of magnitude relative to the maximum TPL signal attainable from a cell with the same dye excited and collected by the same PCF. Biophotonic implications of this waveguide TPL-response enhancement include fiber-format solutions for online monitoring of drug delivery and drug activation, interrogation of neural activity, biosensing, endoscopy, and locally controlled singlet oxygen generation in photodynamic therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Iluminação
/
Fibras Ópticas
/
Medições Luminescentes
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Appl Opt
Ano de publicação:
2009
Tipo de documento:
Article