Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.
Exp Neurol
; 221(1): 129-35, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19853606
ABSTRACT
Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, reverses the seizure behavior and stabilizes the spontaneous electroencephalogram activity. The perinatal intervention provides a pathway to reverse potential birth defects and ameliorate seizures in the adult.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Fator de Crescimento de Hepatócito
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Suscetibilidade a Doenças
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Ácido gama-Aminobutírico
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Interneurônios
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Inibição Neural
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Neurol
Ano de publicação:
2010
Tipo de documento:
Article