Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network.
FEBS Lett
; 583(22): 3704-10, 2009 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-19878677
ABSTRACT
The von Hippel-Lindau (VHL) tumor suppressor gene is a protein interaction hub, controlling numerous genes implicated in tumor progression. Here we focus on structural aspects of protein interactions for a list of 35 experimentally verified protein VHL (pVHL) interactors. Using structural information and computational analysis we have located three distinct interaction interfaces (A, B, and C). Interface B is the most versatile, recognizing a refined linear motif present in 17 otherwise non-related proteins. It has been possible to distinguish compatible and exclusive interactions by relating pVHL function to interaction interfaces and subcellular localization. A novel hypothesis is presented regarding the possible function of the N-terminus as an inhibitor of pVHL function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Estrutura Terciária de Proteína
/
Proteína Supressora de Tumor Von Hippel-Lindau
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2009
Tipo de documento:
Article