Novel B cell therapeutic targets in transplantation and immune-mediated glomerular diseases.
Clin J Am Soc Nephrol
; 5(1): 142-51, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-20007678
ABSTRACT
B cells and antibodies play an important role in the alloresponse to renal grafts as well as in immune-mediated glomerular diseases. In transplantation, greater recognition and improved diagnosis of antibody-mediated rejection have been a catalyst to the introduction of newer drugs and regimens that target B cells, plasma cells, and donor-specific antibodies to improve the outcome associated with antibody-mediated rejection. In immune-mediated renal disease, novel and more selective B cell therapies are gradually modifying the traditional therapeutic approach that consists of steroids and other immunosuppressants. A new era of selective and more effective immunosuppression agents that target the humoral response is finally emerging in transplantation and renal diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Linfócitos B
/
Transplante de Rim
/
Nefropatias
/
Glomérulos Renais
Limite:
Humans
Idioma:
En
Revista:
Clin J Am Soc Nephrol
Ano de publicação:
2010
Tipo de documento:
Article