[Liver fibrosis - pathogenesis and novel therapeutic approaches]. / Pathophysiologie der Leberfibrose : Aktuelle Aspekte und neue Ansätze für antifibrotische Therapien.
Internist (Berl)
; 51(1): 21-9, 2010 Jan.
Article
em De
| MEDLINE
| ID: mdl-20012930
ABSTRACT
Chronic liver injury, such as viral hepatitis, alcohol, metabolic syndrome or other toxic damages, leads to an inflammatory response including the infiltration and activation of immune cells and to the proliferation and transdifferentiation of mesenchymal cells within the liver, especially of hepatic stellate cells. These cells produce an excess of extracellular matrix proteins that are deposited in the liver. Hepatic fibrosis may progress to liver cirrhosis and liver failure. This review aims at summarizing the current view on the pathogenic sequence during fibrogenesis highlighting the essential role of cytokines and chemokines. Understanding the complex cellular interactions in liver fibrosis may help to develop novel antifibrotic therapies in the near future.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunossupressores
/
Fígado
/
Cirrose Hepática
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
De
Revista:
Internist (Berl)
Ano de publicação:
2010
Tipo de documento:
Article