Of guinea pigs and men--an unusual case of jaundice.
Z Gastroenterol
; 48(1): 33-7, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-20072994
ABSTRACT
A 21-year-old male presented at the emergency room with jaundice, itching, dry cough, malaise and weight loss of 10 kg during the preceding four weeks. Eighteen months earlier, the patient had suffered an automobile accident leading to polytrauma. Serological markers for viral or other causes of hepatitis were absent. For suspected secondary sclerosing cholangitis, ultrasound and ERCP were performed but failed to reveal pathological findings. A liver biopsy showed cholestatic liver disease without signs of portal field-associated hepatitis. Hepato-biliary scintigraphy demonstrated hepatocellular dysfunction. The patient finally mentioned his guinea pig farm with around 50 animals, 20 of which had recently died for unknown reasons. The patient and three of his guinea pigs were subsequently tested for serological evidence of leptospirosis. IgG and IgM antibodies reacting with Leptospira interrogans were detected in the patient's serum, and all 3 guinea pigs were serologically positive for serovar Bratislava. Bacterial culture was not successful, and also PCR tests remained negative. The clinical symptoms quickly resolved after the initiation of antibiotic therapy with amoxicillin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
/
Zoonoses
/
Icterícia Obstrutiva
/
Doenças dos Trabalhadores Agrícolas
/
Leptospira interrogans
/
Leptospirose
/
Criação de Animais Domésticos
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Z Gastroenterol
Ano de publicação:
2010
Tipo de documento:
Article